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Factors That Impact the Severity of Relapse

Factors That Impact the Severity of Relapse:

  • Size of lesion(s)
  • Destructiveness of lesion(s)
  • Location of lesion(s). For instance, in spinal cord, we tend to see more severe symptoms than in certain parts of the brain.
  • Short-term treatments (eg steroids)
  • Disease-modifying therapies
  • The burden of pre-existing damage. This gets into the concept of neurologic reserve: If you have same size and type and destructiveness of a lesion in one person who has a greater pre-existing burden of disease compared to someone else who has very minimal pre-existing disease, that person who has less pre-existing disease might not experience quite as severe of symptoms as a person with larger existing burden of disease.
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